NEWS and EVENTS

Meeting agenda draft for 05/17/2017

Photo by Jerry Harb

AGENDA

UCI Malaria Initiative meeting May 17, 10:30-3:00pm, 4248 McGaugh Hall

Anthony A. James, James Lab Staff

Ethan Bier

Gregory Lanzaro

John Marshall

Collaborator meeting UCI, UCSD, UCB

May 17, 2017

Room 4248 McGaugh Hall, UCI

10:30- 4:00PM (lunch provided)

Items

Introductions
Administrative

a. Interactive projects

i. TIGS

ii. UCI MI (BMGF)

iii. DARPA UCR

iv. DARPA Broad/MIT

b. Initiative website(s)

c. Forward copies of regulatory documents as approved

d. Lists of team members and responsibilities by UC

3. Improvements to Plasmodium falciparum effector molecules

a. Mosquito promoters

i. An. stephensi

ii. An. gambiae

III. Midgut

1. G12

2. Peritrophic matrix 1

iv. hemolymph

1.Vitellogenin

b. Single-chain antibodies

i. Existing

1. Pfs 25 4B7

2. CSP 2A10

3. Chitinase 1C3

ii. Synthetic

1. Pfs 25

2. Pfs 47

3. Pfs 230

4. CSP

5. Chitinase

6. HAP2

c. Other effectors

i. Mosquito ligands (SM1)

ii. Antimicrobial peptides

iii. Atreptic immunity (FREP1)

4. P. vivax effector molecules

a. Catalog of target molecules

i. Conserved surface proteins in midgut stages of parasites

5. Improvements to gene drive machinery

a. Options for sex-specific drive and screening approaches

i. Males only

1. Testes promoter searches

a. B2 tubulin

b. Phf7

c. Snail

d. Topi

e. Others

ii. Females only

1. Female promoter searches

a. nanos

iii. Pipeline for analysis

1. RT-PCR

2. In situ hybridization

iv. New gene discovery

1. Dissections

2. RNA-seq

b. Genomic target sites

i. Locus with load (kh^w)

ii. Neutral locus

iii. Positive (additional effector phenotypes [e.g.FREP1])

6. Cas9 helper lines

a. Vasa-Cas9 in attP80.9 fully marked

i. Removal of marker genes

b. Dominant, no load visible marker gene candidates

c. Recessive, no load visible marker genes

i. yellow

ii. ebony

iii. others?

7. Options for challenge assays

a. Plasmodium falciparum

i. Existing

1. UCSD

2. NIH

ii. To develop

1. UCSD

2. UCI

b. Plasmodium vivax

i. India

ii. other

8. Modelling priorities

9. Genome projects

a. Domestic pipeline options

b. Indian pipeline options

c. Target species

i. Anopheles culicifacies

ii. An. stephensi

iii. An. subpictus

iv. An. fluviatilis

v. An. minimus

vi. An. dirus

vii. An. sundaicus

viii. An. baimaii

ix. Aedes aegypti

x. Ae. albopictus

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Current Action Items

Status Updates

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Project Status: PLANNING

Project Manager	Sentelle Eubanks; 949-824-2606 sentelle@uci.edu
Start Date	04/01/17
Projected End Date	03/30/22

Days Remaining

Project Team Members

(use '@username' to list team members below)

aajames@uci.edu
rhodellv@uci.edu
sentelle@uci.edu

Meeting Schedule:

05/17/2017 Room 3248 -UC, Irvine McGaugh Hall
1. Dial-In: 8667401260 (N/A)
2. Enter Access Code: ####### (N/A)

Project Scope:

project scope item #1 Team Portal
project scope item #2 Hiring of Team
project scope item #3 Evaluation field sites

Project Deliverables :

project deliverable item #1 Team Portal
project deliverable item #2 Regulatory
project deliverable item #3

UCIMI Team Portal