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NEWS and EVENTS

Meeting agenda draft for 05/17/2017

Photo by Jerry Harb

AGENDA

UCI Malaria Initiative meeting May 17, 10:30-3:00pm, 4248 McGaugh Hall

Anthony A. James, James Lab Staff

Ethan Bier

Gregory Lanzaro

John Marshall

 

Collaborator meeting UCI, UCSD, UCB

May 17, 2017

Room 4248 McGaugh Hall, UCI

10:30- 4:00PM (lunch provided)

Items

  1. Introductions
  2. Administrative

             a. Interactive projects

                            i. TIGS

                            ii. UCI MI (BMGF)

                            iii. DARPA UCR

                            iv. DARPA Broad/MIT

               b. Initiative website(s)

               c. Forward copies of regulatory documents as approved

               d. Lists of team members and responsibilities by UC

        3. Improvements to Plasmodium falciparum effector molecules

              a. Mosquito promoters

                           i. An. stephensi

                           ii. An. gambiae

                          III. Midgut

                                       1. G12

                                       2. Peritrophic matrix 1

                           iv.   hemolymph

                                       1.Vitellogenin

                 b. Single-chain antibodies

                           i. Existing

                                         1. Pfs 25 4B7

                                         2. CSP 2A10

                                         3. Chitinase 1C3

                           ii. Synthetic

                                          1. Pfs 25

                                          2. Pfs 47

                                          3. Pfs 230

                                          4. CSP

                                          5. Chitinase

                                          6. HAP2

                  c. Other effectors

                            i. Mosquito ligands (SM1)

                            ii. Antimicrobial peptides

                            iii. Atreptic immunity (FREP1)

 

        4. P. vivax effector molecules

                  a. Catalog of target molecules

                           i. Conserved surface proteins in midgut stages of parasites

 

        5. Improvements to gene drive machinery

                  a. Options for sex-specific drive and screening approaches

                           i. Males only

                                          1. Testes promoter searches

                                                      a. B2 tubulin

                                                      b. Phf7

                                                      c. Snail

                                                      d. Topi

                                                      e. Others

                            ii. Females only

                                          1. Female promoter searches

                                                       a. nanos

                             iii. Pipeline for analysis

                                           1. RT-PCR

                                           2. In situ hybridization

                             iv. New gene discovery

                                           1. Dissections

                                           2. RNA-seq

                  b. Genomic target sites

                              i. Locus with load (khw)

                              ii. Neutral locus

                              iii. Positive (additional effector phenotypes [e.g.FREP1])

 

Cas9 helper lines

Vasa-Cas9 in attP80.9 fully marked

Removal of marker genes

Dominant, no load visible marker gene candidates

Recessive, no load visible marker genes

yellow

ebony

others?

 

Options for challenge assays

Plasmodium falciparum

Existing

UCSD

NIH

To develop

UCSD

UCI

Plasmodium vivax

India

other

 

Modelling priorities

 

Genome projects

Domestic pipeline options

Indian pipeline options

Target species

Anopheles culicifacies

An. stephensi

 An. subpictus

 An. fluviatilis

 An. minimus

 An. dirus

 An. sundaicus

 An. baimaii

 Aedes aegypti

 Ae. albopictus

 

 

 

 

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Current Action Items

Status Updates

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Project Status: PLANNING 

Project Manager
Sentelle Eubanks;
949-824-2606 sentelle@uci.edu
Start Date

04/01/17

Projected End Date

03/30/22

Days Remaining

Project Team Members

(use '@username' to list team members below)

  • aajames@uci.edu
  • rhodellv@uci.edu
  • sentelle@uci.edu

 

Meeting Schedule:

05/17/2017 Room 3248 -UC, Irvine McGaugh Hall
1. Dial-In: 8667401260 (N/A)
2. Enter Access Code: ####### (N/A)

Project Scope:

  • project scope item #1 Team Portal
  • project scope item #2 Hiring of Team
  • project scope item #3 Evaluation field sites

Project Deliverables :

  • project deliverable item #1 Team Portal
  • project deliverable item #2 Regulatory
  • project deliverable item #3


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