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Meeting agenda draft for 05/17/2017

 

AGENDA

UCI Malaria Initiative meeting May 17, 10:30-3:00pm, 4248 McGaugh Hall

Anthony A. James, James Lab Staff

Ethan Bier

Gregory Lanzaro

John Marshall

Collaborator meeting UCI. UCSD, UCB

May 17, 2017

Room 4248 McGaugh Hall, UCI

10:30- 4:00

 

 

1)    Introductions

2)    Improvements to Plasmodium falciparum effector molecules

  1. Mosquito promoters
    1.                                                              i.      An. stephensi
    2.                                                            ii.      An. gambiae
    3.                                                         iii.      Midgut
      1. G12
      2. Peritrophic matrix 1
    4.                                                          iv.      hemolymph
      1. Vitellogenin
  2. Single-chain antibodies
    1.                                                              i.      Existing
      1. Pfs 25 4B7
      2. CSP 2A10
      3. Chitinase 1C3
    2.                                                            ii.      Synthetic
      1. Pfs 25
      2. Pfs 47
      3. Pfs 230
      4. CSP
      5. Chitinase

 

3)    P. vivax effector molecules

  1. Catalog of target molecules
    1.                                                              i.      Conserved surface proteins in midgut stages of parasites

 

4)    Improvements to gene drive machinery

  1. Options for sex-specific drive and screening approaches
    1.                                                              i.      Males only
      1. Testes promoter searches
        1. B2 tubulin
        2. Phf7
        3. Snail
        4. Tumi
        5. Others
    2.                                                            ii.      Females only
      1. Female promoter searches
        1.  nanos
  2. Genomic target sites
    1.                                                              i.      Locus with load (khw)
    2.                                                            ii.      Neutral locus
    3.                                                         iii.      Positive (additional effector phenotypes [e.g.FREP1])

 

5)    Options for challenge assays

  1. Plasmodium falciparum
    1.                                                              i.      Existing
      1. UCSD
      2. NIH
    2.                                                            ii.      To develop
      1. UCSD
      2. UCI
  2. Plasmodium vivax
    1.                                                              i.      India

6)    Modelling priorities

 

7)    Action items

 

 

0%

Current Action Items

  1. handler

    Create UCIMI Team Web Portal

    Priority MEDIUM
    sentelle
    May 02, 2017
  2. handler

    Track Regulatory Approvals

    Priority MEDIUM
    sentelle
    May 02, 2017
  3. handler

    Collaboration Meeting 05/17/2017 McGaugh Hall 3rd floor 4248 Irvine, CA

    Priority MEDIUM
    sentelle
    May 04, 2017
  4. handler

    Hiring Staff

    Priority MEDIUM
    sentelle
    May 10, 2017

Status Updates

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Project Status: PLANNING 

Project Manager
Sentelle Eubanks;
949-824-2606 sentelle@uci.edu
Start Date

04/01/17

Projected End Date

03/30/22

Days Remaining

Project Team Members

(use '@username' to list team members below)

  • aajames@uci.edu
  • rhodellv@uci.edu
  • sentelle@uci.edu

 

Meeting Schedule:

05/17/2017 Room 3248 -UC, Irvine McGaugh Hall
1. Dial-In: 8667401260 (N/A)
2. Enter Access Code: ####### (N/A)

Project Scope:

  • project scope item #1 Team Portal
  • project scope item #2 Hiring of Team
  • project scope item #3 Evaluation field sites

Project Deliverables :

  • project deliverable item #1 Team Portal
  • project deliverable item #2 Regulatory
  • project deliverable item #3


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