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USDA VS inspection 11/09/2017 Pass , inspection report 93-R-0434 PASS
IBC Approval 0610/1102/2018 2019 1999-471 Approved 3 year
IACUC inspection 10/23/2018 UC Jan-16-2019 to Jan-16-2022 UC Irvine Pass
| ISSUING AGENCY | DOCUMENT TYPE | REFERENCE | DATE APPROVED | EXPIRATION DATE | ||
| CDC 12/21/2017 | Import Permit Policy Statement: Date and Conditions of the Import Permit (Section 71.54(d) of these regulations provides that the CDC permit is valid only for: (1) the time period and/or term indicated on the permit, and (2) only for so long as the permit conditions continue to be met.) | "The requested vectors are not capable of transferring an infectious biological agent to a human if it is uninfected; therefore, an import permit is not required. | " | 10252017-10037 | 6/11/14 | N/A |
| UCI-IACUC | Expression of Exogenous Genes in Mosquitoes | Protocol No. 1998-1411-9 | 3/10/16 | 3/9/19 | ||
| Centers for Disease Control & Prevention (CDC) | Permit to Import Infectious Biological Agents, Infectious Substances, and Vectors | PHS PERMIT NO. 2016-06-052 | 6/13/16 | 6/13/17 | ||
| UCI- Institutional Biosafety Committee | Expression of Exogenous Genes in Mosquitoes | IBC Protocol Number: 1999-471 | 10/4/16 | 10/3/19 | ||
| USDA-APHIS | ROUTINE INSPECTION - No non-compliant items identified during the inspection. | 1/24/17 | ||||
| UCI Radiation Safety Committee | RADIATION USE AUTHORIZATION | RUA#: R 8906 | 3/17/17 | 3/31/20 | ||
| PATH | Material Transfer Agreement - frozen aliquots proprietary | Protocol No. 1998-1411-9 | 5/2/17 | 9/30/20 | ||
| NIAID | Collaboration Agreement HNIH Carolina Barillas-Mury proprietary | Protocol No. 1998-1411-9 | 5/2/17 | |||
| USDA- | APHISAPHIS (DARPA) | US Veterinary Permit for Importation and Transportation of Controlled Materials and Organisms and Vectors | Permit No. 135681 | 8/12/17 | 8/12/18 | |
| USDA-APHIS | Application 17299032 for University of California, Irvine for Aedes (mosquito eggs) - Aedes aegypti Higgs (Submitted 26 Oct 2017) | Ref. No. 17299032 | 8/12/17 | 12/8/18 | ||
| USDA | Interstate Movement of Anopheles gambiae | PERMIT NO. 17-233-101m | 9/7/17 | 9/7/18 | ||
| UCI and PENN STATE | Non-disclosure Agreement (Processes, designs, sequences, data and findings related to CRISPR/Cas9 and its uses for genome editing and gene regulation) | NDA | 9/25/17 | |||
| California Department of Public Health | Authorizing UCI the continued usage and importation of the new Aedes aegypti strain for vector control | Signed: Vicki Kramer, Chief of Vector-Borne Disease Section | 10/13/17 | |||
| USDA inspection IACUC | Pre inspection prior to permit | 18-004-106m | 11/7/17 | at will | ||
| UCSD MTA TIGS | Material Transfer agreement for Anopheles gambiae and stephensi | MTA00009219 | 1/30/18 | |||
| USDA-APHIS 01/17/2018m interstate only, notified CDPH if movement within state (intrastate) | DARPA Akbari Aedes aegypti eggs Vector 986G-pBac-Aedes-Ubiq (AAEL006511)-dCas9-VPR-p10-UTR-Opie2-dsRed Vector 986H-pBac-Aedes-AAEL011410 (AaKLC2)-dCas9-VPR-p10-UTR-Opie2-eGFP Vector 1002-pBac-3xp3-eGFP-UTR-AAEL010097-RGR-dmeFlightN-UVW-iSce1CutSite-XYZ-optimized-tdTomato_Attb-Modified Vector 1003-pBac-3xp3-tdTomato-AEEL010097-Cas9-HR5Ie1-XYZ-Sce1-Sce1-UVW-eGFP-UTR_attB-Modified | 18-004-106m | 2/2/18 | 2/1/19 | ||
| USDA John Hopkins University | Anopheles stephensi 44c LINE | 18-012-101m | 2/22/18 | 2/22/19 | ||
| USDA to UC Davis | Permit to Import Infectious Biological Agents, Infectious Substances, and Vectors | 136098 | 2/28/18 | |||
| UCSD MTA DARPA | Material Transfer agreement for Aedes aegypti | MTA 94443 | 4/6/18 | |||
| John Hopkins University (Fidel Zavala MD) | Trap P berghei CSP P vivax CS repeat | MTA | 4/17/18 | 4/18/19 | ||
| Leids University (Shahid Kahn) | Pf CelTOS (NF54), Pv CelTOS, Pf CSP (NF54-full), PvCSP variant 210 full, Pv CSP variant 247 full, Pf TRAP NF54, Pv TRAP, Pf CSP/TRAP NF4, Pv CSP/TRAP, Pv CSP/TRAP/CelTOS | MTA | 5/2/18 | |||
| SLA | Pfs14M etal | MTA/SLA | 5/2/18 | |||
| USDA (UCIMI)interstate only, notified CDPH if movement within state (intrastate) | pCO-6-pSL_attB_AgvasCas9DsRed_3xP3CFP (VASA) and (Nanos) interstate transport for injection at UMD X1 gambiae | 18-100-103m | 5/7/18 | 5/4/19 | ||
| Leidos.com (Gabriel Gutierrez) | PFCelTos (Hybridoma sequence for 3C3 clone) | MTA | 5/14/18 | |||
| UCI/UCSD USDA Interstate to UMD | 80.9 Helper line to UMD for injection from UCI (vasa cas9) | 18-141-101m | 6/13/18 | 6/13/19 | ||
| UCI Outgoing to UCSD TIGS Ethan Bier | Material Transfer agreement for Anopheles stephensi (research lines) 80.9 docking site submitted 06/12/2018 | MTA | 6/27/18 | 6/27/18 | ||
| USDA UCI Outgoing to UMD | Stephensi docking site 80.9 | 18-163-113-m | 6/29/18 | 7/1/19 | ||
| USDA Outgoing and incoming UMD UCI | Stephensi lines UMD PENDING helper line | 18-165-104m | 7/23/18 | 7/23/19 | ||
| UCSD DARPA | Akbari OutAkbari Out and In UMD for injection | Aedes Aegypti 1002B and 1003B | 181-191-103m | 7/25/18 | 7/31/19 | |
| Letter from STP | Acceptance of year 1 proposal to UC Davis, sample collection | N/REFa 1191p.n.6/GMS/18 | 9/14/18 | 9/13/19 | ||
| UMD to and from UCI USDA | X1 and Good direction + pC0-19 and pC0-28 gambiae | 18-260-101 | 9/28/18 | 9/28/19 | ||
| UMD to UCI Interstae USDA | Good Direction gambiae pC0-6 | 180-256-103 | 10/2/18 | pending | ||
| UC Irvine /TIGS | IndiaIndia (Items deemed commercially availble and no MTA required) | Plasmid GS62894-2 pET-26b(+)-311_AA Plasmid GS62894-3 pET-26b(+)-317_AA Plasmid GD26894-1 pET-26b(+)-m2A10-_AA | MTA | N/A | N/A | |
| Department of Health & Human Services (DHHS) | Approval to import infectious biological agents, infectious substances or vectors | |||||
| UC Davis BUA #311 | IBC BUA approval Analysis of host pathogen interactions in Drosophila and Mosquito and CRISPR based drives | 311 | 11/26/18 | 2/12/21 | ||
| USDA UC Davis | Permit to Import Infectious Biological Agents, Infectious Substances, and Vectors | 136098/app #18053016 | 11/24/18 | |||
| IBC | UCI BUA | 1999-471 | 6/11/18 | 3/19/19 | ||
| UCSD Beir UCI MTA | 80.9 Helper line and 80.9 docking site | MTA | 1/11/19 | N/A | ||
| IACUC UCI AUP-18-189 | 3 year renewal IACUC Exongenous genes of mosquitoes | 18-189 | 1/16/22 | 1/16/22 | ||
| LOI (letter of Intent) | Union of Comoros Ministry of Health Solidarity Social Protections and Gender Promotion (vector control Comoro Islands) | 1/28/19 | ||||
| USDA permit outgoing JHU | AgCd1(lines) gambiae GATES | 19-061-101m | 4/8/19 | 4/8/20 | ||
| USDA import permit | Ag Vasa helper line Institut de Biologie Moléculaire et Cellulaire, France | 19-093-104m | 4/19/19 | 4/19/20 | ||
| IRB Exemtion UCSD | IRB exemption for survey questionnaires UCIMI A17-0209-002 | 1436188-1 | 5/22/19 | |||
| JH to UCI USDA | A gambiae Permit not required | 19207007 | 7/26/19 | |||
| JH to UCI CDPH | Permission granted to ship A gambiae eggs | 7/26/19 | ||||
| UC Davis USDA permit to import | Dead mosquitoes in silica or 70% ETOH/Live unifected mosquitoe larvae Anopheles gambiae | 136098 | 2/13/19 | 2/13/20 | ||
| UC Davis CDC | Permit to import Biological Agents and vectors | 20181210-099aA | 11/1/19 | 1/11/20 | ||
| Leidos request to move 3C3 UCSD/TIGS | 3C3 mAb request to trasfer to UCSD/TIGS | 9/9/19 | pending | |||
| LUMC | ||||||
| UC Davis CDC | Permit to import Biological Agents and vectorsAlive or dead mosquito eggs, larvae, and adults (Anopheles stephensi, Anopheles gambiae, Anopheles funestus, Anopheles coluzzi, Anopheles darlingi, Aedes aegypti, Aedes albopictus, Anopheles sundiacus). | 20190502-2768A | 9/3/19 | 9/3/20 | ||
| MTA UCI to UCSD DARPA | MTA multi line | MCA S00920 | 4/27/17 | FE | ||
| UCI to UCSD and JHU | 44c Anopheles stephensi 44c | 19-263-102m | 9/22/19 | pending | ||
| UCI to UCSD and JHU | kh recoded | 19-274-103m | 10/1/19 | pending | ||
| UCI to NIH | IB2 insertion locus | 19-290-101m | 10/17/19 | pending | ||
| UCI to NIH | 3C3 effector locus | 19-290-102m | 10/24/19 | 10/23/20 |
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