NEWS and EVENTS
Meeting agenda draft for 05/17/2017
Photo by Jerry Harb
AGENDA
UCI Malaria Initiative meeting May 17, 10:30-3:00pm, 4248 McGaugh Hall
Anthony A. James, James Lab Staff
Ethan Bier
Gregory Lanzaro
John Marshall
Collaborator meeting UCI, UCSD, UCB
May 17, 2017
Room 4248 McGaugh Hall, UCI
10:30- 4:00PM (lunch provided)
Items
- Introductions
- Administrative
a. Interactive projects
i. TIGS
ii. UCI MI (BMGF)
iii. DARPA UCR
iv. DARPA Broad/MIT
b. Initiative website(s)
c. Forward copies of regulatory documents as approved
d. Lists of team members and responsibilities by UC
3. Improvements to Plasmodium falciparum effector molecules
a. Mosquito promoters
i. An. stephensi
ii. An. gambiae
III. Midgut
1. G12
2. Peritrophic matrix 1
iv. hemolymph
1.Vitellogenin
b. Single-chain antibodies
i. Existing
1. Pfs 25 4B7
2. CSP 2A10
3. Chitinase 1C3
ii. Synthetic
1. Pfs 25
2. Pfs 47
3. Pfs 230
4. CSP
5. Chitinase
6. HAP2
c. Other effectors
i. Mosquito ligands (SM1)
ii. Antimicrobial peptides
iii. Atreptic immunity (FREP1)
4. P. vivax effector molecules
a. Catalog of target molecules
i. Conserved surface proteins in midgut stages of parasites
5. Improvements to gene drive machinery
a. Options for sex-specific drive and screening approaches
i. Males only
1. Testes promoter searches
a. B2 tubulin
b. Phf7
c. Snail
d. Topi
e. Others
ii. Females only
1. Female promoter searches
a. nanos
iii. Pipeline for analysis
1. RT-PCR
2. In situ hybridization
iv. New gene discovery
1. Dissections
2. RNA-seq
b. Genomic target sites
i. Locus with load (khw)
ii. Neutral locus
iii. Positive (additional effector phenotypes [e.g.FREP1])
Cas9 helper lines
Vasa-Cas9 in attP80.9 fully marked
Removal of marker genes
Dominant, no load visible marker gene candidates
Recessive, no load visible marker genes
yellow
ebony
others?
Options for challenge assays
Plasmodium falciparum
Existing
UCSD
NIH
To develop
UCSD
UCI
Plasmodium vivax
India
other
Modelling priorities
Genome projects
Domestic pipeline options
Indian pipeline options
Target species
Anopheles culicifacies
An. stephensi
An. subpictus
An. fluviatilis
An. minimus
An. dirus
An. sundaicus
An. baimaii
Aedes aegypti
Ae. albopictus
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Status UpdatesAdd a blog post and tag it with the label (enter project label here and edit in blog_post macro below) to have it appear in the recently updated content list below
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Project updates are due 12/15/2019
If you have any questions, please call or email me.
Payments have been for years 3-5 expect by November 23
949-824-2606
Sentelle@uci.edu
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Project Team Members(use '@username' to list team members below)
Meeting Schedule:0508/1703/2017 Room 3248 -UC, Irvine McGaugh Hall 1. Dial-In: 8667401260 (N/A) 2. Enter Access Code: ####### (N/A)Omar Akbari UCR 02/20-21/2018 Omar UCSD 08/04/2017 UCIMI 01/24/2018 UCIMI Workshop 04/05/2018 FNIH Regulatory Meeting 06/04-06/05/2018 Site Selection 08/02/2018 UCIMI (date pending) 12/14/2018 Akbari meeting 01/31/2019-0201/2019 UCI MI Annual workshop 04/01/2019 Subawards under review 1/30/2019 UCIMI 1/29/2019 UCIMI Project Scope:
Project Deliverables :
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