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Meeting agenda draft for 05/17/2017

 

AGENDA

UCI Malaria Initiative meeting May 17, 10:30-3:00pm, 4248 McGaugh Hall

Anthony A. James, James Lab Staff

Ethan Bier

Gregory Lanzaro

John Marshall

Collaborator meeting UCI. UCSD, UCB

May 17, 2017

Room 4248 McGaugh Hall, UCI

10:30- 4:00

 

 

1)    Introductions

2)    Improvements to Plasmodium falciparum effector molecules

  1. Mosquito promoters
    1.                                                              i.      An. stephensi
    2.                                                            ii.      An. gambiae
    3.                                                         iii.      Midgut
      1. G12
      2. Peritrophic matrix 1
    4.                                                          iv.      hemolymph
      1. Vitellogenin
  2. Single-chain antibodies
    1.                                                              i.      Existing
      1. Pfs 25 4B7
      2. CSP 2A10
      3. Chitinase 1C3
    2.                                                            ii.      Synthetic
      1. Pfs 25
      2. Pfs 47
      3. Pfs 230
      4. CSP
      5. Chitinase

 

3)    P. vivax effector molecules

  1. Catalog of target molecules
    1.                                                              i.      Conserved surface proteins in midgut stages of parasites

 

4)    Improvements to gene drive machinery

  1. Options for sex-specific drive and screening approaches
    1.                                                              i.      Males only
      1. Testes promoter searches
        1. B2 tubulin
        2. Phf7
        3. Snail
        4. Tumi
        5. Others
    2.                                                            ii.      Females only
      1. Female promoter searches
        1.  nanos
  2. Genomic target sites
    1.                                                              i.      Locus with load (khw)
    2.                                                            ii.      Neutral locus
    3.                                                         iii.      Positive (additional effector phenotypes [e.g.FREP1])

 

5)    Options for challenge assays

  1. Plasmodium falciparum
    1.                                                              i.      Existing
      1. UCSD
      2. NIH
    2.                                                            ii.      To develop
      1. UCSD
      2. UCI
  2. Plasmodium vivax
    1.                                                              i.      India

6)    Modelling priorities

 

7)    Action items

 

 

Tasklist
titleCurrent Action Items
||Completed||Priority||Locked||CreatedDate||CompletedDate||Assignee||Name||
|F|M|F|1493755796794|          |sentelle|Create UCIMI Team Web Portal|
|F|M|F|1493762381088|          |sentelle|Track Regulatory Approvals|
|F|M|F|1493927333292|          |sentelle|Collaboration Meeting 05/17/2017 McGaugh Hall 3rd floor 4248 Irvine, CA|
|F|M|F|1494430729865|          |sentelle|Hiring Staff|
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Status Updates

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Project updates are due 12/15/2019

If you have any questions, please call or email me.

Payments have been for years 3-5 expect by November 23

 

949-824-2606  

Sentelle@uci.edu

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Excerpt

Project Status:
Status
colourYellow
title

Planning

FIeld Collection
 

Project Manager
Sentelle Eubanks;
949-824-2606 sentelle@uci.edu
Start Date

04/01/17

Projected End Date

03/30/22

Days Remaining

Project Team Members

(use '@username' to list team members below)

 

Meeting Schedule:

0508/1703/2017 Room 3248 -UC, Irvine McGaugh Hall
1. Dial-In: 8667401260 (N/A)
2. Enter Access Code: ####### (N/A)Omar Akbari UCR
02/20-21/2018 Omar UCSD
08/04/2017 UCIMI
01/24/2018 UCIMI Workshop
04/05/2018 FNIH Regulatory Meeting
06/04-06/05/2018 Site Selection
08/02/2018 UCIMI (date pending)
12/14/2018 Akbari meeting
01/31/2019-0201/2019 UCI MI Annual workshop
04/01/2019 Subawards under review
1/30/2019 UCIMI
1/29/2019 UCIMI

Project Scope:

  • project scope item #1 Team Portal done
  • Project scope communication plan Complete
  • project scope item #2 Hiring of Team done
  • project scope item #3 Evaluation field sites in Complete
  • project aim community engagement plan in progress
  • Project scope item #4 Team meetings in progress
  • Project scope Community Engagement in progress
  • Project Scope Independent Risk Assessment 06/2018under revision
  • Project Scope Site selection 07/2018 STP/COMOROS
  • Project Scope Community Engagement 09/01/2018 STP Davis
  • Project scope Field collection 11/2019
  • Project scope CE 11/2019
  • Project Scope Capacity Building TBD

Project Deliverables :

  • project deliverable item #1 Team Portal complete
  • project deliverable item #2 Regulatoryproject deliverable item #3  #2 Team Members Hired complete
  • deliverable item #3 Evaluation of sites in progress
    • Community Engagement plan in progress
  • Deliverable item #4 Team Meetings in progress
  •  Site Selection
  • Community Engagement begin 09/01/2018
  • Gene Drive complete 011/01/2018
  • Effector molecules (Prioritized)12/01/2018
  • Effector Molecules revised 01/20/2020
  • Annual meeting 01/29/2020
  • Subcontract renewals revised
  • GATES revised submission