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Meeting agenda draft for 05/17/2017

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Photo by Jerry Harb

AGENDA

UCI Malaria Initiative meeting May 17, 10:30-3:00pm, 4248 McGaugh Hall

Anthony A. James, James Lab Staff

Ethan Bier

Gregory Lanzaro

John Marshall

Collaborator meeting UCI. UCSD, UCB

May 17, 2017

Room 4248 McGaugh Hall, UCI

10:30- XXXX

Items

1. Introductions
2. Improvements to Plasmodium falciparum effector molecules

                    a) Mosquito promoters

                                           i.     An. stephensi

                                          ii.     An. gambiae

                                          iii.     Midgut

1. G12
2. Peritrophic matrix 1

                                           iv.     hemolymph

1.    Vitellogenin

                       b) Single-chain antibodies

                                           i.     Existing

                                                     1. Pfs 25 4B7

                                                     2. CSP 2A10

                                                     3. Chitinase 1C3

                                            ii.     Synthetic

                                                     1. Pfs 25

                                                     2. Pfs 47

                                                     3. Pfs 230

                                                     4. CSP

                                                     5. Chitinase

                           c) Other effectors

                                              i.     Mosquito ligands (SM1)

                                            ii.     Antimicrobial peptides

                                          iii.     Atreptic immunity (FREP1)

3)    P. vivax effector molecules

                           a.     Catalog of target molecules

                                             i.     Conserved surface proteins in midgut stages of parasites

4)    Improvements to gene drive machinery

                            a.     Options for sex-specific drive and screening approaches

                                              1.     Males only

                                                      1.    Testes promoter searches

                                                                a.     B2 tubulin

                                                                b.    Phf7

                                                                c.     Snail

                                                                d.    Topi

                                                                e.     Others

                                            ii.     Females only

                                                      1.    Female promoter searches

                                                               a.      Nanos

                                          iii.     Pipeline for analysis

                                                       1.    RT-PCR

                                                       2.    In situ hybridization

                                           iv.     New gene discovery

                                                        1.    Dissections

                                                        2.    RNA-seq

                                    b.    Genomic target sites

                                              i.     Locus with load (kh^w)

                                            ii.     Neutral locus

                                          iii.     Positive (additional effector phenotypes [e.g.FREP1])

5)    Options for challenge assays

                                   a.     Plasmodium falciparum

                                              i.     Existing

                                                       1.    UCSD

                                                       2.    NIH

                                            ii.     To develop

                                                      1.    UCSD

                                                      2.    UCI

                                     b.    Plasmodium vivax

                                              i.     India

                                            ii.     other

                                      6)    Cas9 helper lines

7)    Modelling priorities

8)    Administrative

                           a.     Interactive projects

                                            i.     TIGS

                                           ii.     UCI MI (BMGF)

                                          iii.     DARPA UCR

                                          iv.     DARPA Broad/MIT

b.     Initiative website(s)

c.     Forward copies of regulatory documents as approved

d.    Lists of team members and responsibilities by UC

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